Bone Marrow Lesions in the Knee: Treatment in Palm Beach
Bone marrow lesions (BMLs), also called bone marrow edema, are areas of inflammation and fluid accumulation within the bone tissue just beneath the cartilage surface of the knee. Research increasingly identifies BMLs as a primary driver of knee pain in osteoarthritis, often more closely associated with pain than cartilage loss alone.
At Palm Beach Regenerative, Dr. Ghattas addresses bone marrow lesions as part of a comprehensive knee treatment approach, using Intraosseous (IO) injection techniques that deliver orthobiologic material directly to the affected bone area. Give us a call today to learn more.
What Are Bone Marrow Lesions?
Bone marrow lesions appear on MRI as areas of abnormal signal within the subchondral bone, which is the bone layer directly beneath the joint surface. They represent a state of inflammation and structural stress within the bone that can be a significant pain generator in arthritic and injured knees.
Addressing the subchondral bone environment, not just the joint space, is an important distinction in the Palm Beach Regenerative approach to knee care.
Signs and Symptoms
- Deep, aching knee pain, often described as pain within the bone rather than the surface
- Pain at rest as well as with activity
- Swelling around the knee
- Pain that may not fully respond to standard joint injections
- Often occurs alongside or mistaken for general knee arthritis symptoms
Common Causes and Risk Factors
- Osteoarthritis with associated mechanical overload on the subchondral bone
- Acute knee injuries with bone bruising
- Repetitive stress loading on the joint
- Obesity increasing compressive forces on the knee
- Prior knee injuries or surgeries
How It Is Diagnosed
Bone marrow lesions are identified on MRI. They do not appear on standard X-rays. Dr. Ghattas reviews MRI findings to assess the size, location, and significance of any bone marrow edema as part of your knee evaluation.
The presence of BMLs can inform which treatment approach is most appropriate: standard joint injection alone, or a combined joint and intraosseous treatment strategy.
Conventional Treatment Options
Bone marrow lesions are often undertreated in conventional care because they may not be recognized as a primary pain source:
- Activity modification and unloading to reduce compressive stress
- Weight management to decrease mechanical load
- Physical therapy focused on joint mechanics and muscle balance
- Standard anti-inflammatory medications (typically offering limited benefit for bone-level inflammation)
- Bisphosphonate medications have been studied for BMLs with variable results
The Palm Beach Regenerative Approach
At Palm Beach Regenerative, bone marrow lesions are addressed through Intraosseous (IO) injection, a technique that delivers concentrated platelet or bone marrow preparations directly into the subchondral bone, targeting the inflammatory environment where BMLs occur.
IO injection is typically combined with a standard intra-articular (joint space) injection for a comprehensive approach to knee joint health.
All procedures are performed under real-time fluoroscopic guidance to confirm accurate needle placement within the bone.
The BioMod Advantage: At Palm Beach Regenerative, treatment does not end with a single injection. Through our BioMod Lab, Dr. Ghattas may combine your orthobiologic procedure with MLS Robotic Laser Therapy to reduce inflammation and support tissue recovery, alongside customized Xymogen supplement protocols designed to optimize your body’s healing environment. This integrated, concierge approach is what sets Palm Beach Regenerative apart from a standard injection clinic.
Like all medical procedures, interventional orthobiologics have potential risks and benefits. Results vary by individual. Not all patients are candidates. Dr. Ghattas will discuss your specific situation, realistic expectations, and all treatment options, including when surgery or other interventions may be more appropriate.
NEXT STEP
Consultations Are Usually Available Within 1 to 2 Weeks
Request a consultation or call (561) 501-3900.
●PATIENT OUTCOMES
Patient Experiences
"I had severe knee pain and was looking for proper knee pain treatment, which is how I found Dr. Ghattas on Instagram. I was a bit hesitant at first, but it turned out to be one of the best decisions I’ve made for my health. Francia was amazing at coordinating all my consultations and making the whole process easy and stress-free. If you’re dealing with knee pain and looking for a reliable doctor and team, I highly recommend them."
Roger L
"Over a year ago, both my daughter and I underwent PRP treatment with Dr. Ghattas—PRP for my left knee and PRP for my daughter’s L4-L5 and sacral region. We wanted to wait long enough to truly evaluate the results before sharing our experience. I am pleased to say that the outcomes have been outstanding. My daughter’s improvement has been remarkable, and the treatment has made a significant difference in her quality of life. I have also experienced excellent results with my knee. Dr. Ghattas is an exceptional physician who combines expertise, professionalism, and genuine care for his patients. We are incredibly grateful for the treatment we received and the positive impact it has had on our lives. Thank you, Dr. Ghattas. We are truly grateful for everything you have done. You are simply the best."
Dr Jorge A
“Apart from the exemplary personal service by the reception and the staff that makes us feel we're at home at the clinic, I have experienced remarkable healing in several episodes from shoulder issue to knee injuries and hip pain. The doctor is so thorough in the diagnosis phase that he administered exactly what was needed, no more no less! Thank you folks for a wonderful experience.”
RG G
“I am quite active and go to pilates 3-4 times per week. I was having left knee pain and which was treated with PRP. It took about 3 months for me to feel better but then the pain completely subsided. I now am able to exercise without the fear that I will tear a ligament and am pain free.”
Ellipsis P
"The Regenexx process has been nothing short of amazing. The pre-treatment MRI (performed at an independent facility) indicated that my knee was far worse than the physical symptoms I was experiencing. The treatment process was exactly as Dr. Ghattas explained...."
Tymira M
These testimonials reflect the real-life experiences of patients with the Regenexx protocol but are not necessarily typical of what you or any other patient might experience. Individual results of the procedures using Regenexx lab processes will vary depending on a number of factors, including your diagnosis, the severity of your condition, your overall health, and others. To better understand what large numbers of patients experience on average, please visit the Patient Results page, and inquire with a physician within the licensed Regenexx network near you.







